Cytokines (CKs) are involved in the mechanisms of sleep induction, and, in particular, interleukin-1 (IL-1) and tumor necrosis factor-alpha seem to play an important role in the slow-wave sleep. Here are reported two cases of normal sleep and altered sleep in which plasma levels of IL-1 beta have been determined. In the subject with a normal sleep a dramatic increase of this CK has been observed, while beta-endorphin levels were reduced. In the light of these findings, the role of sleep in the host protection is discussed.

Somnogenic cytokines with special reference to interleukin-1 / Covelli, Vito; Cannuscio, B; Munno, I; Altamura, M; Decandia, P; Pellegrino, Nm; Maffione, Ab; Savastano, Silvia; Lombardi, Gaetano. - In: ACTA NEUROLOGICA. - ISSN 0001-6276. - STAMPA. - 13:6(1991), pp. 520-526.

Somnogenic cytokines with special reference to interleukin-1.

COVELLI, VITO;SAVASTANO, SILVIA;LOMBARDI, GAETANO
1991

Abstract

Cytokines (CKs) are involved in the mechanisms of sleep induction, and, in particular, interleukin-1 (IL-1) and tumor necrosis factor-alpha seem to play an important role in the slow-wave sleep. Here are reported two cases of normal sleep and altered sleep in which plasma levels of IL-1 beta have been determined. In the subject with a normal sleep a dramatic increase of this CK has been observed, while beta-endorphin levels were reduced. In the light of these findings, the role of sleep in the host protection is discussed.
1991
Somnogenic cytokines with special reference to interleukin-1 / Covelli, Vito; Cannuscio, B; Munno, I; Altamura, M; Decandia, P; Pellegrino, Nm; Maffione, Ab; Savastano, Silvia; Lombardi, Gaetano. - In: ACTA NEUROLOGICA. - ISSN 0001-6276. - STAMPA. - 13:6(1991), pp. 520-526.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/334849
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