This study was aimed to investigate the effect of 3,4 secoisopimara-4(18),7,15-trien-3-oic acid (compound 1) isolated from the aerial parts of Salvia cinnabarina, on upper gastrointestinal transit in mice in vivo. Compound 1 (10 - 100 mg/kg, i. p.) dose-dependently delayed gastrointestinal motility. Pretreatment ( i. p.) of mice with hexamethonium (10 mg/kg), naloxone (2 mg/kg), N(G)-nitro- L-arginine-methyl ester ( L-NAME) (25 mg/kg) or yohimbine (1 mg/kg) did not modify the inhibitory effect of compound 1 (50 mg/kg). However, the L-type Ca (2+) channel verapamil (5 mg/kg, i. p.) significantly reduced the antimotility effect of compound 1 (50 mg/kg). These results suggest that compound 1 inhibits gastrointestinal motility in mice. The effect could involve, at least in part, L-type Ca (2+) channels.

A diterpenoid from Salvia cinnabarina inhibits mouse intestinal motility in vivo / Capasso, Raffaele; Izzo, ANGELO ANTONIO; Capasso, Francesco; G., Romussi; A., Bisio; Mascolo, NICOLA DOMENICO C. FERDINANDO. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 70:(2004), pp. 375-377. [10.1055/s-2004-818954]

A diterpenoid from Salvia cinnabarina inhibits mouse intestinal motility in vivo

CAPASSO, RAFFAELE;IZZO, ANGELO ANTONIO;CAPASSO, FRANCESCO;MASCOLO, NICOLA DOMENICO C. FERDINANDO
2004

Abstract

This study was aimed to investigate the effect of 3,4 secoisopimara-4(18),7,15-trien-3-oic acid (compound 1) isolated from the aerial parts of Salvia cinnabarina, on upper gastrointestinal transit in mice in vivo. Compound 1 (10 - 100 mg/kg, i. p.) dose-dependently delayed gastrointestinal motility. Pretreatment ( i. p.) of mice with hexamethonium (10 mg/kg), naloxone (2 mg/kg), N(G)-nitro- L-arginine-methyl ester ( L-NAME) (25 mg/kg) or yohimbine (1 mg/kg) did not modify the inhibitory effect of compound 1 (50 mg/kg). However, the L-type Ca (2+) channel verapamil (5 mg/kg, i. p.) significantly reduced the antimotility effect of compound 1 (50 mg/kg). These results suggest that compound 1 inhibits gastrointestinal motility in mice. The effect could involve, at least in part, L-type Ca (2+) channels.
2004
A diterpenoid from Salvia cinnabarina inhibits mouse intestinal motility in vivo / Capasso, Raffaele; Izzo, ANGELO ANTONIO; Capasso, Francesco; G., Romussi; A., Bisio; Mascolo, NICOLA DOMENICO C. FERDINANDO. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 70:(2004), pp. 375-377. [10.1055/s-2004-818954]
File in questo prodotto:
File Dimensione Formato  
Planta Med salvia transit 2004.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 88.4 kB
Formato Adobe PDF
88.4 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/333702
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 20
social impact