Herein we report an efficient solid-phase synthesis of some N-1-alkyl-substituted analogs of cyclic inosinediphosphate-ribose (cIDPR), a mimic of cyclic ADP-ribose (cADPR) which has been described as an agonist of the cADPR/Ca2+ signalling system. The proposed synthetic strategy uses a polystyrene support bearing inosine by a 2',3'-acetal linkage which is converted into several N-1-alkylinosine-bis-phosphate derivatives which in turn were cyclized by a solid-phase pyrophosphate bond formation.

Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach / Oliviero, Giorgia; D'Errico, Stefano; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Piccialli, Gennaro; Mayol, Luciano. - In: NUCLEIC ACIDS SYMPOSIUM SERIES. - ISSN 0261-3166. - 52:(2008), pp. 573-574. [10.1093/nass/nrn290]

Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach.

OLIVIERO, GIORGIA;D'ERRICO, STEFANO;BORBONE, NICOLA;AMATO, JUSSARA;PICCIALLI, VINCENZO;VARRA, MICHELA;PICCIALLI, GENNARO;MAYOL, LUCIANO
2008

Abstract

Herein we report an efficient solid-phase synthesis of some N-1-alkyl-substituted analogs of cyclic inosinediphosphate-ribose (cIDPR), a mimic of cyclic ADP-ribose (cADPR) which has been described as an agonist of the cADPR/Ca2+ signalling system. The proposed synthetic strategy uses a polystyrene support bearing inosine by a 2',3'-acetal linkage which is converted into several N-1-alkylinosine-bis-phosphate derivatives which in turn were cyclized by a solid-phase pyrophosphate bond formation.
2008
Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach / Oliviero, Giorgia; D'Errico, Stefano; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Piccialli, Gennaro; Mayol, Luciano. - In: NUCLEIC ACIDS SYMPOSIUM SERIES. - ISSN 0261-3166. - 52:(2008), pp. 573-574. [10.1093/nass/nrn290]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/331430
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