The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.

Optical Tweezers as a probe for oligoeoxyribonucleotide structuration / Borbone, Nicola; Oliviero, Giorgia; Amato, Jussara; Piccialli, Gennaro; Mayol, Luciano; Miccio, L.; Pesce, Giuseppe; Sasso, Antonio. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1295-1299. [10.1080/15257770701530541]

Optical Tweezers as a probe for oligoeoxyribonucleotide structuration

BORBONE, NICOLA;OLIVIERO, GIORGIA;AMATO, JUSSARA;PICCIALLI, GENNARO;MAYOL, LUCIANO;PESCE, GIUSEPPE;SASSO, ANTONIO
2007

Abstract

The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.
2007
Optical Tweezers as a probe for oligoeoxyribonucleotide structuration / Borbone, Nicola; Oliviero, Giorgia; Amato, Jussara; Piccialli, Gennaro; Mayol, Luciano; Miccio, L.; Pesce, Giuseppe; Sasso, Antonio. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1295-1299. [10.1080/15257770701530541]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/331190
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