A relation between age and serum phosphate levels in adults has been recognized since 1969.1 We used data from the Gubbio Population Study to analyze serum phosphate levels and renal phosphate handling in relation to age in 2107 men and 2560 women (age range, 18 to 97 years). In adults, serum phosphate levels decline with age, except for a transient increase during the perimenopausal period in women. The age-associated decline in serum phosphate levels reflects changes in tubular phosphate reabsorption, which, in turn, might be explained by age-dependent changes in tubular phosphate handling or in its hormonal modulators (e.g., parathyroid hormone, phosphatonins, and growth hormone

Age, renal tubular phosphate reabsorption, and serum phosphate levels in adults.

Cirillo M.;CIACCI, CAROLINA;
2008

Abstract

A relation between age and serum phosphate levels in adults has been recognized since 1969.1 We used data from the Gubbio Population Study to analyze serum phosphate levels and renal phosphate handling in relation to age in 2107 men and 2560 women (age range, 18 to 97 years). In adults, serum phosphate levels decline with age, except for a transient increase during the perimenopausal period in women. The age-associated decline in serum phosphate levels reflects changes in tubular phosphate reabsorption, which, in turn, might be explained by age-dependent changes in tubular phosphate handling or in its hormonal modulators (e.g., parathyroid hormone, phosphatonins, and growth hormone
File in questo prodotto:
File Dimensione Formato  
NEJM_08_082118.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 164 kB
Formato Adobe PDF
164 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/330924
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 83
  • ???jsp.display-item.citation.isi??? 80
social impact