To evaluate the role of polymorphisms in glutathione S-transferase M1 (GSTM1) and theta 1 (GSTT1) as effect modifiers of the association between CA and cancer risk. A case-control study was performed pooling data from cytogenetic studies carried out in 1974-1995 in three laboratories in Italy, Norway, and Denmark. The subjects were classified as low, medium, and high by tertile of CA frequency. The data were analysed by setting up a Bayesian model which included prior information about cancer risk by CA frequency.
Association between frequency of Chromosomal Aberrations and Cancer Risk is not influenced by Genetic Polymorphisms in GSTM1 and GSTT1 / A. M., Rossi; I. L., Hansteen; C. F., Skjelbred; M., Ballardin; V., Maggini; E., Murgia; A., Tomei; Viarengo, Paolo; L. E., Knudsen; R., Barale; H., Norppa; S., Bonassi. - In: ENVIRONMENTAL HEALTH PERSPECTIVES. - ISSN 0091-6765. - STAMPA. - 117:(2009), pp. 203-208. [10.1289/ehp.11769]
Association between frequency of Chromosomal Aberrations and Cancer Risk is not influenced by Genetic Polymorphisms in GSTM1 and GSTT1
VIARENGO, PAOLO;
2009
Abstract
To evaluate the role of polymorphisms in glutathione S-transferase M1 (GSTM1) and theta 1 (GSTT1) as effect modifiers of the association between CA and cancer risk. A case-control study was performed pooling data from cytogenetic studies carried out in 1974-1995 in three laboratories in Italy, Norway, and Denmark. The subjects were classified as low, medium, and high by tertile of CA frequency. The data were analysed by setting up a Bayesian model which included prior information about cancer risk by CA frequency.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
