The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.

Effect of O6-methylguanine on the stability of G-quadruplex DNA / C. S., Mekmaysy; Petraccone, Luigi; N. C., Garbett; P. A., Ragazzon; R., Gray; J. O., Trent; J. B., Chaires. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - STAMPA. - 130 (21):21(2008), pp. 6710-6711. [10.1021/ja801976h]

Effect of O6-methylguanine on the stability of G-quadruplex DNA.

PETRACCONE, LUIGI;
2008

Abstract

The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.
2008
Effect of O6-methylguanine on the stability of G-quadruplex DNA / C. S., Mekmaysy; Petraccone, Luigi; N. C., Garbett; P. A., Ragazzon; R., Gray; J. O., Trent; J. B., Chaires. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - STAMPA. - 130 (21):21(2008), pp. 6710-6711. [10.1021/ja801976h]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/311358
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 59
  • ???jsp.display-item.citation.isi??? 53
social impact