Newpolymeric composite materials containing a nanohybrid to be used for the controlled release of an antibiotic molecule, chloramphenicol succinate, have been formulated, prepared and characterised. The nanohybrid consists of a layered double hydroxide of Mg–Al hydrotalcitetype, in which the nitrate anions present in the host galleries were replaced with chloramphenicol succinate anions (CFS−) by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15mm thickness. The composite materials were analysed by X-ray diffractometry and thermogravimetry and their mechanical properties were determined. They showed properties even better than those of the pristine polymer. The release process of the antibiotic molecules was found to be very interesting and promising for tuneable drug delivery. It consists of two stages: an initial stage of a very rapid burst, in which a small fraction of drug is released; and a second stage that is much slower, extending for a longer and longer time. This behaviour is profoundly different and much slower than that of a sample in which the antibiotic molecule is directly incorporated into the polymeric matrix. The parameters influencing drug release have been individuated and discussed.

Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release / Sammartino, Gilberto; Marenzi, Gaetano; Tammaro, L.; Bolognese, Adele; Calignano, Antonio; Costantino, U.; Califano, Luigi; Mastrangelo, F.; Tete, S.; Vittoria, V.. - In: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0192-0561. - STAMPA. - 19:(2006), pp. 55-62.

Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release

SAMMARTINO, GILBERTO;MARENZI, GAETANO;BOLOGNESE, ADELE;CALIGNANO, ANTONIO;CALIFANO, LUIGI;
2006

Abstract

Newpolymeric composite materials containing a nanohybrid to be used for the controlled release of an antibiotic molecule, chloramphenicol succinate, have been formulated, prepared and characterised. The nanohybrid consists of a layered double hydroxide of Mg–Al hydrotalcitetype, in which the nitrate anions present in the host galleries were replaced with chloramphenicol succinate anions (CFS−) by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15mm thickness. The composite materials were analysed by X-ray diffractometry and thermogravimetry and their mechanical properties were determined. They showed properties even better than those of the pristine polymer. The release process of the antibiotic molecules was found to be very interesting and promising for tuneable drug delivery. It consists of two stages: an initial stage of a very rapid burst, in which a small fraction of drug is released; and a second stage that is much slower, extending for a longer and longer time. This behaviour is profoundly different and much slower than that of a sample in which the antibiotic molecule is directly incorporated into the polymeric matrix. The parameters influencing drug release have been individuated and discussed.
2006
Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release / Sammartino, Gilberto; Marenzi, Gaetano; Tammaro, L.; Bolognese, Adele; Calignano, Antonio; Costantino, U.; Califano, Luigi; Mastrangelo, F.; Tete, S.; Vittoria, V.. - In: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0192-0561. - STAMPA. - 19:(2006), pp. 55-62.
File in questo prodotto:
File Dimensione Formato  
308462.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 311.54 kB
Formato Adobe PDF
311.54 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/308462
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact