We describe an MDS patient showing neutropenia, CD14+CD56+ monocytosis and polyclonal expansion of NK cells. A defective HLA-E expression on myeloid lineage, the constitutive presence of CD178 on the CD14+CD56+ monocytes combined with expansion of CD94/NKG2A+ CD94/NKG2C+ NK cells are proposed to be relevant for the pathogenesis of this haematopoietic disorder
Titolo: | A Case of Myelodysplastic syndrome associated with CD14+CD56+ monocytosis, expansion of NK lymphocytes and defect of HLA-E expression | |
Autori: | ||
Data di pubblicazione: | 2009 | |
Rivista: | ||
Abstract: | We describe an MDS patient showing neutropenia, CD14+CD56+ monocytosis and polyclonal expansion o...f NK cells. A defective HLA-E expression on myeloid lineage, the constitutive presence of CD178 on the CD14+CD56+ monocytes combined with expansion of CD94/NKG2A+ CD94/NKG2C+ NK cells are proposed to be relevant for the pathogenesis of this haematopoietic disorder | |
Handle: | http://hdl.handle.net/11588/304460 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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