The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.
Masculinization of XX Drosophila transgenic flies expressing Ceratitis capitata DSXM isoform / Saccone, Giuseppe; Salvemini, Marco; Pane, Attilio; Polito, Catello. - In: THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. - ISSN 1696-3547. - 52:8(2008), pp. 1051-1057. [10.1387/ijdb.082657gs]
Masculinization of XX Drosophila transgenic flies expressing Ceratitis capitata DSXM isoform.
SACCONE, GIUSEPPE;SALVEMINI, MARCO;PANE, ATTILIO;POLITO, CATELLO
2008
Abstract
The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.| File | Dimensione | Formato | |
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