CaM kinase II, a regulator of synaptic plasticity, is implicated in pathophysiology and pharmacology of psychiatric disorders. Chronic treatment with antidepressants desipramine and reboxetine up-regulated CaM kinase II in neuronal cell bodies of hippocampus. mRNA/protein expression for alphaCaM kinase II was unchanged, whereas Thr phosphorylation was increased in pyramidal/granular cell bodies, suggesting that increased phosphorylation is responsible for kinase activation. Short-term treatment of neuronal cultures with reboxetine reduced kinase activation in a concentration-dependent manner. The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.

Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation / Tiraboschi, E; Giambelli, R; D'Urso, Giordano; Galietta, A; Barbon, A; DE BARTOLOMEIS, Andrea; Gennarelli, M; Barlati, S; Racagni, G; Popoli, M.. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 15:15(2004), pp. 2393-2396.

Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation

D'URSO, GIORDANO;DE BARTOLOMEIS, ANDREA;
2004

Abstract

CaM kinase II, a regulator of synaptic plasticity, is implicated in pathophysiology and pharmacology of psychiatric disorders. Chronic treatment with antidepressants desipramine and reboxetine up-regulated CaM kinase II in neuronal cell bodies of hippocampus. mRNA/protein expression for alphaCaM kinase II was unchanged, whereas Thr phosphorylation was increased in pyramidal/granular cell bodies, suggesting that increased phosphorylation is responsible for kinase activation. Short-term treatment of neuronal cultures with reboxetine reduced kinase activation in a concentration-dependent manner. The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.
2004
Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation / Tiraboschi, E; Giambelli, R; D'Urso, Giordano; Galietta, A; Barbon, A; DE BARTOLOMEIS, Andrea; Gennarelli, M; Barlati, S; Racagni, G; Popoli, M.. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 15:15(2004), pp. 2393-2396.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/302404
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