A one-pot synthesis of homodimeric proteins is described. The synthetic strategy is based on a double expressed protein ligation reaction between thioester peptides and a new bis-cysteinyl linker. The protocol was also applied to the synthesis of heterodimers
Semisynthesis of Dimeric Proteins by Expressed Protein Ligation / B., Ziaco; S., Pensato; L. D., D’Andrea; Benedetti, Ettore; Romanelli, Alessandra. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 10:10(2008), pp. 1955-1958. [10.1021/ol800457g]
Semisynthesis of Dimeric Proteins by Expressed Protein Ligation
BENEDETTI, ETTORE;ROMANELLI, ALESSANDRA
2008
Abstract
A one-pot synthesis of homodimeric proteins is described. The synthetic strategy is based on a double expressed protein ligation reaction between thioester peptides and a new bis-cysteinyl linker. The protocol was also applied to the synthesis of heterodimersFile in questo prodotto:
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