Recently we reported a preliminary study on the structure of two novel quadruplex structures, Q33 and Q55, formed by the oligodeoxynucleotides 5'TGG3'-3'GGT5' and 3'TGG5'-5'GGT3', resp. Here we report their soln. structures at the at. level. The obtained structures reveal that Q55 and Q33 possess a different stacking among G-quartets and different twist angle (and therefore different helical winding) at the inversion of polarity level.
Molecular Modelling Studies of Four Stranded Quadruplexes Containing a 3’-3’ or 5’-5’ Inversion of Polarity Site / Virno, Ada; Zaccaria, Francesco; Virgilio, Antonella; Esposito, Veronica; Galeone, Aldo; Mayol, Luciano; Randazzo, Antonio. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:8-9(2007), pp. 1139-1143. [10.1080/15257770701521888]
Molecular Modelling Studies of Four Stranded Quadruplexes Containing a 3’-3’ or 5’-5’ Inversion of Polarity Site
VIRNO, ADA;ZACCARIA, FRANCESCO;VIRGILIO, ANTONELLA;ESPOSITO, VERONICA;GALEONE, ALDO;MAYOL, LUCIANO;RANDAZZO, ANTONIO
2007
Abstract
Recently we reported a preliminary study on the structure of two novel quadruplex structures, Q33 and Q55, formed by the oligodeoxynucleotides 5'TGG3'-3'GGT5' and 3'TGG5'-5'GGT3', resp. Here we report their soln. structures at the at. level. The obtained structures reveal that Q55 and Q33 possess a different stacking among G-quartets and different twist angle (and therefore different helical winding) at the inversion of polarity level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
