A further chemical investigation of the Caribbean marine sponge Aplysina archeri led to the isolation of a novel bromocompound, archerine (1). Its structure was established through extensive NMR spectroscopy, including 1H-13C HSQC, 1H-13C HMBC and 1H-15N HMBC experiments, as well as positive FAB MS/MS spectra. The capability of archerine to chelate zinc ions was investigated. Archerine exhibited antihistamine activity on the isolated guinea pig ileum at concentrations as low as 1 uM.

Archerine, a Novel Anti-Histaminic Bromotyrosine-Derived Compound from the Caribbean Marine Sponge Aplysina archeri

CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;
2001

Abstract

A further chemical investigation of the Caribbean marine sponge Aplysina archeri led to the isolation of a novel bromocompound, archerine (1). Its structure was established through extensive NMR spectroscopy, including 1H-13C HSQC, 1H-13C HMBC and 1H-15N HMBC experiments, as well as positive FAB MS/MS spectra. The capability of archerine to chelate zinc ions was investigated. Archerine exhibited antihistamine activity on the isolated guinea pig ileum at concentrations as low as 1 uM.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/205097
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