A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13, 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.

Chemistry of Verongida Sponges 9. Secondary Metabolite Composition of the Caribbean Sponge Aplysina cauliformis

CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;
1999

Abstract

A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13, 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/205091
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