A procedure for the synthesis of enantiopure β3-amino acids from proteinogenic α-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected β3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-protected chiral synthons, such as 2-aminoalcohols, 2-aminoiodides, and β3-amino nitriles.
Enantiopure b3-amino acids-2,2-d2 via homologation of proteinogenic a-amino acids / Caputo, Romualdo; Longobardo, Luigi. - In: AMINO ACIDS. - ISSN 0939-4451. - STAMPA. - 32:(2007), pp. 401-404. [10.1007/s00726-006-0384-0]
Enantiopure b3-amino acids-2,2-d2 via homologation of proteinogenic a-amino acids
CAPUTO, ROMUALDO;LONGOBARDO, LUIGI
2007
Abstract
A procedure for the synthesis of enantiopure β3-amino acids from proteinogenic α-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected β3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-protected chiral synthons, such as 2-aminoalcohols, 2-aminoiodides, and β3-amino nitriles.File in questo prodotto:
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