A simple synthetic strategy was developed to prepare amphiphilic biodegradable poly(ether-ester)s based in PCL ann PEO, which contain along the chain pendant amino groups available for attachment of aminoacid sequences. -OH terminated PCL macromers with one Z-protected pendant-NH2 group per chain were prepared by ROP of caprolactone using a novel diamino functionalized initiator based on L-Lysine and were chain extended with -COCl terminated PEO. Deprotection of NH2 groups did not cause chain cleavage.
Poly(e-caprolactone)-poly(oxyethylene) Multiblck Copolymers Bearing Along he Chain Regularly Spaced Pendant Amino Groups / M., Canciello; Maglio, Giovanni; G., Nese; Palumbo, Rosario. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - STAMPA. - 7:4(2007), pp. 491-499. [10.1002/mabi.200600261]
Poly(e-caprolactone)-poly(oxyethylene) Multiblck Copolymers Bearing Along he Chain Regularly Spaced Pendant Amino Groups
MAGLIO, GIOVANNI;PALUMBO, ROSARIO
2007
Abstract
A simple synthetic strategy was developed to prepare amphiphilic biodegradable poly(ether-ester)s based in PCL ann PEO, which contain along the chain pendant amino groups available for attachment of aminoacid sequences. -OH terminated PCL macromers with one Z-protected pendant-NH2 group per chain were prepared by ROP of caprolactone using a novel diamino functionalized initiator based on L-Lysine and were chain extended with -COCl terminated PEO. Deprotection of NH2 groups did not cause chain cleavage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
