Bone implants must simultaneously satisfy many requirements, even though the surface properties remain a crucial aspect in osseointegration success. Since a single material with a uniform structure cannot satisfy all of these requirements, composite materials specifically designed for orthopedic or dental implant application should be envisaged. Two poly(methylmethacrylate)/hydroxyapatite composites reinforced by E-glass fibers, uncoated (PMMA/HA/Glass) and poly(2-hydroxyethyl methacrylate) (PMMA/HA/Glass+pHEMA) coated by the biomimetic method, were mech. (push-out test) and histomorphometrically (Affinity Index, Al) investigated in an in vivo rabbit model. Cylindrical implants (0 2 mm × 5 mm length) were inserted into rabbit femoral cortical (mid-diaphysis) and cancelous (distal epiphysis) bone, under general anesthesia. The highest values of push-out force and ultimate shear strength were obsd. for the PMMA/HA/Glass at 12 wk, which significantly (p < 0.001) differed from those of PMMA/HA/Glass+pHEMA at the same exptl. time and from those of PMMA/HA/Glass at 4 wk. At both exptl. times, significantly (p < 0.0005) lower values of Al were obsd. in the PMMA/HA/Glass+pHEMA vs. PMMA/HA/Glass (distal femoral epiphysis: 4 wk = 33%; 12 wk = 19%; femoral diaphysis: 4 wk = 15%; 12 wk = 11%). The good mech. and histomorphometric results obtained with PMMA/HA/Glass should be followed by further evaluation of bone remodeling processes and mech. strength around loaded PMMA/HA/Glass implants at longer exptl. times. Finally, the biomimetic method applied to pHEMA needs to be further investigated in order to improve the pos. effect of SBF on pHEMA and to enhance the coating adhesion.

Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments / Giavaresi, G.; Branda, Francesco; Causa, Filippo; Luciani, Giuseppina; Fini, M.; ALDINI N., Nicoli; Rimondini, L.; Ambrosio, Luigi; Giardino, R.. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - ELETTRONICO. - 27(8):(2004), pp. 674-680.

Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments

BRANDA, FRANCESCO;CAUSA, FILIPPO;LUCIANI, GIUSEPPINA;AMBROSIO, LUIGI;
2004

Abstract

Bone implants must simultaneously satisfy many requirements, even though the surface properties remain a crucial aspect in osseointegration success. Since a single material with a uniform structure cannot satisfy all of these requirements, composite materials specifically designed for orthopedic or dental implant application should be envisaged. Two poly(methylmethacrylate)/hydroxyapatite composites reinforced by E-glass fibers, uncoated (PMMA/HA/Glass) and poly(2-hydroxyethyl methacrylate) (PMMA/HA/Glass+pHEMA) coated by the biomimetic method, were mech. (push-out test) and histomorphometrically (Affinity Index, Al) investigated in an in vivo rabbit model. Cylindrical implants (0 2 mm × 5 mm length) were inserted into rabbit femoral cortical (mid-diaphysis) and cancelous (distal epiphysis) bone, under general anesthesia. The highest values of push-out force and ultimate shear strength were obsd. for the PMMA/HA/Glass at 12 wk, which significantly (p < 0.001) differed from those of PMMA/HA/Glass+pHEMA at the same exptl. time and from those of PMMA/HA/Glass at 4 wk. At both exptl. times, significantly (p < 0.0005) lower values of Al were obsd. in the PMMA/HA/Glass+pHEMA vs. PMMA/HA/Glass (distal femoral epiphysis: 4 wk = 33%; 12 wk = 19%; femoral diaphysis: 4 wk = 15%; 12 wk = 11%). The good mech. and histomorphometric results obtained with PMMA/HA/Glass should be followed by further evaluation of bone remodeling processes and mech. strength around loaded PMMA/HA/Glass implants at longer exptl. times. Finally, the biomimetic method applied to pHEMA needs to be further investigated in order to improve the pos. effect of SBF on pHEMA and to enhance the coating adhesion.
2004
Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments / Giavaresi, G.; Branda, Francesco; Causa, Filippo; Luciani, Giuseppina; Fini, M.; ALDINI N., Nicoli; Rimondini, L.; Ambrosio, Luigi; Giardino, R.. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - ELETTRONICO. - 27(8):(2004), pp. 674-680.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/203047
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