The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis / Monti, DARIA MARIA; MONTESANO GESUALDI, Nicola; Matousek, J; Esposito, Franca; D'Alessio, Giuseppe. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 581:(2007), pp. 930-934.
The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis
MONTI, DARIA MARIA;MONTESANO GESUALDI, Nicola;ESPOSITO, FRANCA;D'ALESSIO, GIUSEPPE
2007
Abstract
The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.| File | Dimensione | Formato | |
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