Twelve new diterpenes, named amygdaloidins A-L (1-12), possessing a unique substitution pattern of the jatrophane skeleton, have been isolated from the wood spurge, Euphorbia amygdaloides L. (Euphorbiaceae). The chemical structures of amygdaloidins A-L have been established through a combination of extensive nuclear magnetic resonance and mass spectrometry methods. To deeper investigate the conformations adopted by such compounds in solution, we have carried out a molecular mechanic and dynamics calculation on amygdaloidin A and on the previously isolated euphodendroidin I. The data obtained gave further information on the endo- and exo-type conformations, the two main orientations of the jatrophane diterpenes
Amygdaloidins A-L, twelve new 13 α-OH jatrophane diterpenes from Euphorbia amygdaloides L / Corea, G.; Fattorusso, Caterina; Fattorusso, Ernesto; Lanzotti, V.. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 61:(2005), pp. 4485-4494. [10.1016/j.tet.2005.02.031]
Amygdaloidins A-L, twelve new 13 α-OH jatrophane diterpenes from Euphorbia amygdaloides L.
FATTORUSSO, CATERINA;FATTORUSSO, ERNESTO;LANZOTTI V.
2005
Abstract
Twelve new diterpenes, named amygdaloidins A-L (1-12), possessing a unique substitution pattern of the jatrophane skeleton, have been isolated from the wood spurge, Euphorbia amygdaloides L. (Euphorbiaceae). The chemical structures of amygdaloidins A-L have been established through a combination of extensive nuclear magnetic resonance and mass spectrometry methods. To deeper investigate the conformations adopted by such compounds in solution, we have carried out a molecular mechanic and dynamics calculation on amygdaloidin A and on the previously isolated euphodendroidin I. The data obtained gave further information on the endo- and exo-type conformations, the two main orientations of the jatrophane diterpenesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.