A cluster of four d(TG4T) hexanucleotides with the 3′-ends linked together by a bunchy spacer has been synthesized and shown to form a monomolecular parallel quadruplex 5 in solution characterized by four G-quartets. 1H NMR spectroscopy and CD thermal denaturation experiments indicate the monomolecular quadruplex (5) to be more stable than the tetramolecular counterpart [d(TG4T)]4.
Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution / Oliviero, Giorgia; Borbone, Nicola; Galeone, Aldo; Varra, Michela; Piccialli, Gennaro; Mayol, Luciano. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 45:(2004), pp. 4869-4872. [10.1016/j.tetlet.2004.04.149]
Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution.
OLIVIERO, GIORGIA;BORBONE, NICOLA;GALEONE, ALDO;VARRA, MICHELA;PICCIALLI, GENNARO;MAYOL, LUCIANO
2004
Abstract
A cluster of four d(TG4T) hexanucleotides with the 3′-ends linked together by a bunchy spacer has been synthesized and shown to form a monomolecular parallel quadruplex 5 in solution characterized by four G-quartets. 1H NMR spectroscopy and CD thermal denaturation experiments indicate the monomolecular quadruplex (5) to be more stable than the tetramolecular counterpart [d(TG4T)]4.| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0040403904009682-main 2.pdf
non disponibili
Tipologia:
Abstract
Licenza:
Accesso privato/ristretto
Dimensione
288.02 kB
Formato
Adobe PDF
|
288.02 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
