HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TTAGGG)(4) human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.

Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence.

BORBONE, NICOLA;D'ISA, GIULIANA;OLIVIERO, GIORGIA;PICCIALLI, GENNARO;VARRA, MICHELA;MAYOL, LUCIANO
2005

Abstract

HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TTAGGG)(4) human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/200745
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