Chemical investigation of Santolina insularis afforded eleven germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.
Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis / Appendino, G., Aviello, G., Ballero, M., Borrelli, F., Fattorusso, E., Petrucci, F., Santelia, F.U., TAGLIALATELA SCAFATI, O.. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - STAMPA. - 68:(2005), pp. 853-857. [10.1021/np050120q]
Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis
G. AVIELLO;BORRELLI, FRANCESCA;FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
2005
Abstract
Chemical investigation of Santolina insularis afforded eleven germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
