The liver affects the release and clearance of many hormones, but the interactions between gastrointestinal peptides and liver function have yet to be established. The aim of this study was to evaluate by RIA the serum levels of glucagon, insulin, gastrin, vasoaetive intestinal peptide, gastrin-releasing peptide-GRP, neurotensin, cholecystokinin-CCK, secretin and motilin during acute hepatic cytonecrosis and during liver regeneration in man. The study was performed in ten patients with viral hepatitis (8 virus A and 2 virus B) in the acute phase (alanine transaminase-ALT = 3073 _+ 739 U/L; mean + SEM), and 52 days after the initial evaluation, during clinical and biochemical recovery (ALT = 77+ 26). Only serum GRP and CCK were significantly increased (about 100%; p<0.01) in the acute phase of hepatitis (GRP: 137.6 +_ 21.3 pg/ml; CCK: 56:6 + 7.0 pg/ml); they returned to normal values during convalescence (GRP: 60.2 +_ 7.6; CCK: 31.1 + 3.6). Both these hormones are regulatory signals of food introduction and satiety state, and both are cellular growth factors. In conclusion: 1) the liver, during acute hepatocellular necrosis, seems able to affect serum levels of GRP and CCK thereby interfering with the release and clearance of these hormones; 2) the increased levels of GRP and CCK may be responsible for the dyspepsia or lack of appetite that characterizes the initial phase of acute viral hepatitis; 3) studies should be conducted to verify whether these hormones play a role in the liver regeneration of hepatitis recovery

Gastrointestinal hormones in acute viral hepatitis.

CUOMO, ROSARIO;
1995

Abstract

The liver affects the release and clearance of many hormones, but the interactions between gastrointestinal peptides and liver function have yet to be established. The aim of this study was to evaluate by RIA the serum levels of glucagon, insulin, gastrin, vasoaetive intestinal peptide, gastrin-releasing peptide-GRP, neurotensin, cholecystokinin-CCK, secretin and motilin during acute hepatic cytonecrosis and during liver regeneration in man. The study was performed in ten patients with viral hepatitis (8 virus A and 2 virus B) in the acute phase (alanine transaminase-ALT = 3073 _+ 739 U/L; mean + SEM), and 52 days after the initial evaluation, during clinical and biochemical recovery (ALT = 77+ 26). Only serum GRP and CCK were significantly increased (about 100%; p<0.01) in the acute phase of hepatitis (GRP: 137.6 +_ 21.3 pg/ml; CCK: 56:6 + 7.0 pg/ml); they returned to normal values during convalescence (GRP: 60.2 +_ 7.6; CCK: 31.1 + 3.6). Both these hormones are regulatory signals of food introduction and satiety state, and both are cellular growth factors. In conclusion: 1) the liver, during acute hepatocellular necrosis, seems able to affect serum levels of GRP and CCK thereby interfering with the release and clearance of these hormones; 2) the increased levels of GRP and CCK may be responsible for the dyspepsia or lack of appetite that characterizes the initial phase of acute viral hepatitis; 3) studies should be conducted to verify whether these hormones play a role in the liver regeneration of hepatitis recovery
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/181397
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