The known antimitotic agent eleutherobin and the briarane diterpenoids erythrolides A and B have been isolated from cultured specimens of Erythropodium caribaeorum in amounts comparable to those reported from wild-harvested reef animals. The novel diterpenoid aquariolide A, having an unprecedented highly rearranged carbon skeleton (named aquariane), has also been found. The aquariane skeleton can be formally derived from the briarane skeleton by sequential di-ð-methane and vinyl-cyclopropane rearrangements.
Diterpenoids from Cultured Erythropodium caribareorum / TAGLIALATELA SCAFATI, Orazio; U., DEO JANGRA; M., Campbell; M., Roberge; R. J., Andersen. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 4:(2002), pp. 4085-4088. [10.1021/ol026831m]
Diterpenoids from Cultured Erythropodium caribareorum
TAGLIALATELA SCAFATI, ORAZIO;
2002
Abstract
The known antimitotic agent eleutherobin and the briarane diterpenoids erythrolides A and B have been isolated from cultured specimens of Erythropodium caribaeorum in amounts comparable to those reported from wild-harvested reef animals. The novel diterpenoid aquariolide A, having an unprecedented highly rearranged carbon skeleton (named aquariane), has also been found. The aquariane skeleton can be formally derived from the briarane skeleton by sequential di-ð-methane and vinyl-cyclopropane rearrangements.| File | Dimensione | Formato | |
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