Seven lactone metabolites, namely the known plakortones B-D (1-3), the novel plakortones E (4) and F (5), and two novel lactones, named simplactones A (6) and B (7), have been isolated from the Caribbean sponge Plakortis simplex, and their structures characterized by spectroscopic and chemical means. In addition, the unprecedented amino acid 8 has been isolated from the same source, and a hypothesis of its biogenetic relationship with simplactones is herein reported. Plakortones B-F and compound 8 exhibited in vitro cytotoxic activity on WEHI 164, murine fibrosarcoma cell line.
Metabolites From The Sponge Plakortis simplex. II. Isolation of Four Bioactive Lactone Compounds and of a Novel Related Amino Acid / F., Cafieri; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio; M., DI ROSA; Ianaro, Angela. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 55:(1999), pp. 13831-13840. [10.1016/S0040-4020(99)00866-2]
Metabolites From The Sponge Plakortis simplex. II. Isolation of Four Bioactive Lactone Compounds and of a Novel Related Amino Acid.
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO;IANARO, ANGELA
1999
Abstract
Seven lactone metabolites, namely the known plakortones B-D (1-3), the novel plakortones E (4) and F (5), and two novel lactones, named simplactones A (6) and B (7), have been isolated from the Caribbean sponge Plakortis simplex, and their structures characterized by spectroscopic and chemical means. In addition, the unprecedented amino acid 8 has been isolated from the same source, and a hypothesis of its biogenetic relationship with simplactones is herein reported. Plakortones B-F and compound 8 exhibited in vitro cytotoxic activity on WEHI 164, murine fibrosarcoma cell line.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
