Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.
Novel bromopyrrole alkaloids from the sponge Agelas dispar / F., Cafieri; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - STAMPA. - 61:(1998), pp. 122-125. [10.1021/np970323h]
Novel bromopyrrole alkaloids from the sponge Agelas dispar
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
1998
Abstract
Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.