The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly.
New Solid Phase Approach to Obtain 3'-Derivatized Oligonucleotides / DE NAPOLI, Lorenzo; DI FABIO, Giovanni; Messere, Anna; A., Pepe; Varra, Michela; Piccialli, Gennaro. - In: GAZZETTA CHIMICA ITALIANA. - ISSN 0016-5603. - STAMPA. - 126:(1996), pp. 755-759.
New Solid Phase Approach to Obtain 3'-Derivatized Oligonucleotides
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MESSERE, ANNA;VARRA, MICHELA;PICCIALLI, GENNARO
1996
Abstract
The solid-phase synthesis of 3'-derivatized oligonucleotides, by using a support which links the first nucleoside-3'-phosphate through the nucleobase, is reported. Following this procedure, the marking molecules can easily incorporated in satisfactory yields at the 3'-phosphate terminus either before or after the chain assembly.File in questo prodotto:
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