Ribosylation and glucosylation of the base residues of inosine and uridine have been efficiently achieved using Mitsunobu reaction, leading to the N-1 and 6-O-glycosylinosine and N-3-glycosyluridine derivatives, all with β configuration at the glycosidic carbon. The unprecedented 5-amino-1-(β-D-ribofuranosyl)imidazole-4-[N-(β-D-glucopyranosyl)carboxamide] has also been synthesised.
Synthetic studies on the glycosylation of the base residues of inosine and uridine / DE NAPOLI, L., DI FABIO, G., A., M., Montesarchio, D., Piccialli, G., Varra, M.. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - ELETTRONICO. - 23:(1999), pp. 3489-3493. [10.1039/A906195I]
Synthetic studies on the glycosylation of the base residues of inosine and uridine
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;VARRA, MICHELA
1999
Abstract
Ribosylation and glucosylation of the base residues of inosine and uridine have been efficiently achieved using Mitsunobu reaction, leading to the N-1 and 6-O-glycosylinosine and N-3-glycosyluridine derivatives, all with β configuration at the glycosidic carbon. The unprecedented 5-amino-1-(β-D-ribofuranosyl)imidazole-4-[N-(β-D-glucopyranosyl)carboxamide] has also been synthesised.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
