New nucleoside based solid supports. Synthesis of 5’,3’-derivatized thymidine analogues

Two new thymidine based polymeric supports, in which the nucleosides have been anchored through the thymine moiety to a β-hydroxy thioether functionalized resin via a Mitsunobu reaction, have been prepared. A simple and efficient solid-phase synthesis of 5′,3′-bis-derivatized thymidine analogues has so been developed, following methodologies well established in peptide and oligonucleotide chemistry and is here proposed for the preparation of a variety of different nucleoside conjugate products.