The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.
Solid-phase synthesis of glyco-oligonucleotide conjugates / M., Adinolfi; DE NAPOLI, Lorenzo; DI FABIO, Giovanni; L., Guariniello; Iadonisi, Alfonso; A., Messere; Montesarchio, Daniela; Piccialli, Gennaro. - In: SYNLETT. - ISSN 0936-5214. - ELETTRONICO. - 6:(2001), pp. 745-748. [10.1055/s-2001-14906]
Solid-phase synthesis of glyco-oligonucleotide conjugates
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;IADONISI, ALFONSO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO
2001
Abstract
The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
