The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.
Solid-phase synthesis of glyco-oligonucleotide conjugates / M., A., DE NAPOLI, L., DI FABIO, G., L., G., Iadonisi, A., A., M., Montesarchio, D., Piccialli, G.. - In: SYNLETT. - ISSN 0936-5214. - ELETTRONICO. - 6:(2001), pp. 745-748. [10.1055/s-2001-14906]
Solid-phase synthesis of glyco-oligonucleotide conjugates
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;IADONISI, ALFONSO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO
2001
Abstract
The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.File in questo prodotto:
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