De novo protein design has recently emerged as an attractive approach for studying the structure and function of proteins. This approach critically tests our understanding of the principles of protein folding; only in de novo design must one truly confront the issue of how to specify a protein's fold and function. If we truly understand proteins, it should be possible to design receptors, enzymes, and ion channels from scratch. Further, as this understanding evolves and is further refined, it should be possible to design proteins and biomimetic polymers with properties unprecedented in nature.
De Novo Design and Structural Characterization of Proteins and Metalloproteins / W. F., Degrado; C. M., Summa; Pavone, Vincenzo; Nastri, Flavia; Lombardi, Angelina. - In: ANNUAL REVIEW OF BIOCHEMISTRY. - ISSN 0066-4154. - STAMPA. - 68:(1999), pp. 779-819.
De Novo Design and Structural Characterization of Proteins and Metalloproteins
PAVONE, VINCENZO;NASTRI, FLAVIA;LOMBARDI, ANGELINA
1999
Abstract
De novo protein design has recently emerged as an attractive approach for studying the structure and function of proteins. This approach critically tests our understanding of the principles of protein folding; only in de novo design must one truly confront the issue of how to specify a protein's fold and function. If we truly understand proteins, it should be possible to design receptors, enzymes, and ion channels from scratch. Further, as this understanding evolves and is further refined, it should be possible to design proteins and biomimetic polymers with properties unprecedented in nature.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
