We have investigated the conformational preferences of a newly synthesized C(alpha,alpha) symmetrically disubstituted glycine, namely alpha,alpha-dicyclopropylglycine (Dcp). We report here the crystal structure of a fully protected dipeptide containing Dcp, namely Z-Dcp(1)-Dcp(2)-OCH(3). Both Dcp residues are in a folded conformation. The overall peptide structural organization corresponds to an alpha-pleated sheet conformation, similar to that observed in linear peptides made up of alternating D- and L-residues and in Z-Aib-Aib-OCH(3) (Aib: alpha,alpha-dimethylglycine). These preliminary data suggest that the Dcp could represent an alternative as molecular tool to stabilize folded conformations.
The Crystal Structure of a Dcp containing Peptide / DE SIMONE, G.; Lombardi, Angelina; Galdiero, Stefania; Nastri, Flavia; DI COSTANZO, L.; Gohda, S.; Sano, A.; Yamada, T.; Pavone, Vincenzo. - In: BIOPOLYMERS. - ISSN 1097-0282. - STAMPA. - 53:2(2000), pp. 182-188. [10.1002/(SICI)1097-0282]
The Crystal Structure of a Dcp containing Peptide
LOMBARDI, ANGELINA;GALDIERO, STEFANIA;NASTRI, FLAVIA;L. DI COSTANZO;PAVONE, VINCENZO
2000
Abstract
We have investigated the conformational preferences of a newly synthesized C(alpha,alpha) symmetrically disubstituted glycine, namely alpha,alpha-dicyclopropylglycine (Dcp). We report here the crystal structure of a fully protected dipeptide containing Dcp, namely Z-Dcp(1)-Dcp(2)-OCH(3). Both Dcp residues are in a folded conformation. The overall peptide structural organization corresponds to an alpha-pleated sheet conformation, similar to that observed in linear peptides made up of alternating D- and L-residues and in Z-Aib-Aib-OCH(3) (Aib: alpha,alpha-dimethylglycine). These preliminary data suggest that the Dcp could represent an alternative as molecular tool to stabilize folded conformations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
