A fully protected tripeptide containing a novel Cα,α-disubstituted glycine (α,α-di(2-pyridyl)glycine (2Dpy)) in the central position and Cα,α-dimethylglycine (Aib) in positions 1 and 3 was synthesized and structurally characterized by single crystal X-ray analysis. The 2Dpy residue bears two 2-pyridyl moieties, which may coordinate metal ions, and promote self-assembly of peptide units. All the data obtained in the present work suggest that the 2Dpy residue is well suited to be accommodated into folded conformations. The spontaneous formation of an ordered structure by the 2Dpy containing tri-peptide and copper ions may guide toward the design of more elaborate self-assembling systems.

Conformational and Coordination Properties of a Peptide Containing α,α-di(2-Pyridyl)Glicine, a Linker for Supramolecular Assembly of Proteins / DI COSTANZO, L.; Geremia, S.; Randaccio, L.; Ichino, T.; Yanagihara, R.; Yamada, T.; Marasco, Daniela; Lombardi, Angelina; Pavone, Vincenzo. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - STAMPA. - (2003), pp. 787-792. [10.1039/B209199B]

Conformational and Coordination Properties of a Peptide Containing α,α-di(2-Pyridyl)Glicine, a Linker for Supramolecular Assembly of Proteins

L. DI COSTANZO;MARASCO, DANIELA;LOMBARDI, ANGELINA;PAVONE, VINCENZO
2003

Abstract

A fully protected tripeptide containing a novel Cα,α-disubstituted glycine (α,α-di(2-pyridyl)glycine (2Dpy)) in the central position and Cα,α-dimethylglycine (Aib) in positions 1 and 3 was synthesized and structurally characterized by single crystal X-ray analysis. The 2Dpy residue bears two 2-pyridyl moieties, which may coordinate metal ions, and promote self-assembly of peptide units. All the data obtained in the present work suggest that the 2Dpy residue is well suited to be accommodated into folded conformations. The spontaneous formation of an ordered structure by the 2Dpy containing tri-peptide and copper ions may guide toward the design of more elaborate self-assembling systems.
2003
Conformational and Coordination Properties of a Peptide Containing α,α-di(2-Pyridyl)Glicine, a Linker for Supramolecular Assembly of Proteins / DI COSTANZO, L.; Geremia, S.; Randaccio, L.; Ichino, T.; Yanagihara, R.; Yamada, T.; Marasco, Daniela; Lombardi, Angelina; Pavone, Vincenzo. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - STAMPA. - (2003), pp. 787-792. [10.1039/B209199B]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/147719
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