A systematic study to evaluate the ability of 5'-DNA-3'-p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3'-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex
Synthesis and DNA binding properties of DNA-PNA chimeras / Barone, Guido; DE NAPOLI, Lorenzo; DI FABIO, Giovanni; E., Erra; Giancola, Concetta; A., Messere; Montesarchio, Daniela; Petraccone, Luigi; Piccialli, Gennaro. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - 22:5-8(2003), pp. 1089-1091. [10.1081/NCN-120022743]
Synthesis and DNA binding properties of DNA-PNA chimeras.
BARONE, GUIDO;DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;GIANCOLA, CONCETTA;MONTESARCHIO, DANIELA;PETRACCONE, LUIGI;PICCIALLI, GENNARO
2003
Abstract
A systematic study to evaluate the ability of 5'-DNA-3'-p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3'-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplexI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
