ODNs containing a 3′-3′ phosphodiester linkage as inversion of polarity motif have been shown to cooperatively bind to 5′-(purine)m(pyrimidine)n-3′ type duplexes by specific alternate strand recognition of the adjacent oligopurine domains. An NMR study has been undertaken to investigate the role of the 3′-3′ linked nucleosides and their nearest neighbours in the stabilization of the triple helical complexes.
Studies on alternate strand triple helix formation by oligodeoxyribonucleotides containing a 3'-3' phosphodiester bond / DE NAPOLI, Lorenzo; Galeone, Aldo; Mayol, Luciano; Messere, A.; Montesarchio, Daniela; Pepe, A; Piccialli, Gennaro. - In: NUCLEOSIDES & NUCLEOTIDES. - ISSN 0732-8311. - ELETTRONICO. - 17:9-11(1998), pp. 1709-1716. [10.1080/07328319808004705]
Studies on alternate strand triple helix formation by oligodeoxyribonucleotides containing a 3'-3' phosphodiester bond.
DE NAPOLI, LORENZO;GALEONE, ALDO;MAYOL, LUCIANO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO
1998
Abstract
ODNs containing a 3′-3′ phosphodiester linkage as inversion of polarity motif have been shown to cooperatively bind to 5′-(purine)m(pyrimidine)n-3′ type duplexes by specific alternate strand recognition of the adjacent oligopurine domains. An NMR study has been undertaken to investigate the role of the 3′-3′ linked nucleosides and their nearest neighbours in the stabilization of the triple helical complexes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
