The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.
Solid phase synthesis of 5-hydroxymethyluracil containing DNA / Conte, M. R.; Galeone, Aldo; Avizonis, D.; Hsu, V. L.; Mayol, Luciano; Kearns, D. R.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 2:1(1992), pp. 79-82. [10.1016/S0960-894X(00)80660-5]
Solid phase synthesis of 5-hydroxymethyluracil containing DNA
GALEONE, ALDO;MAYOL, LUCIANO;
1992
Abstract
The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.File in questo prodotto:
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