Four novel xenicane diterpenoids, xenimanadins AeD (1e4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids.
Xenimanadins A-D, a Family of Xenicane Diterpenoids From the Indonesian Soft Coral Xenia sp / Fattorusso, Ernesto; Romano, Adriana; TAGLIALATELA SCAFATI, Orazio; Achmad, M. J.; G., Bavestrello; C., Cerrano. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 64:(2008), pp. 3141-3146. [10.1016/j.tet.2008.01.120]
Xenimanadins A-D, a Family of Xenicane Diterpenoids From the Indonesian Soft Coral Xenia sp.
FATTORUSSO, ERNESTO;ROMANO, ADRIANA;TAGLIALATELA SCAFATI, ORAZIO;
2008
Abstract
Four novel xenicane diterpenoids, xenimanadins AeD (1e4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
