Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed.
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrilylcholinesterase / Savini, L.; Campiani, G.; Gaeta, A.; Pellerano, C.; Fattorusso, Caterina; Chiasserini, L.; Fedorko, J. M.; Saxena, A.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 11:(2001), pp. 1779-1782. [10.1016/S0960-894X(01)00294-3]
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrilylcholinesterase.
FATTORUSSO, CATERINA;
2001
Abstract
Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
