The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely, unrearranged HMGA overexpression is a feature of malignant tumours and is also causally related to neoplastic cell transformation. Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins.

Roles of HMGA proteins in cancer / Fusco, Alfredo; Fedele, Monica. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - STAMPA. - 7:12(2007), pp. 899-910. [10.1038/nrc2271]

Roles of HMGA proteins in cancer.

FUSCO, ALFREDO;FEDELE, MONICA
2007

Abstract

The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely, unrearranged HMGA overexpression is a feature of malignant tumours and is also causally related to neoplastic cell transformation. Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins.
2007
Roles of HMGA proteins in cancer / Fusco, Alfredo; Fedele, Monica. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - STAMPA. - 7:12(2007), pp. 899-910. [10.1038/nrc2271]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/144729
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