Hepatitis C virus (HCV) determines an acute hepatitis evolving to persistent infection in 50–80% of patients. Different mechanisms have been proposed to explain disease evolution, including viral escape, failure of the T helper immune network, and host genetic factors. Among CD4+ T cell subsets, lymphocytes expressing constitutively CD25 (interleukin 2 receptor alpha chain), namely T regulatory cells (Treg), appear to play a critical role in controlling chronic evolution of HCV mediated liver diseases. Here we investigate the frequency and functional activity of CD3+/CD4+/CD25+ Tregs in acute HCV infection in relation to its evolution over time.
Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution / Perrella, A., Vitiello, L., Atripaldi, L., Conti, P., Sbreglia, C., Altamura, S., Patarino, T., Vela, R., Morelli, G., Bellopede, P., Alone, C., Racioppi, L., Perrella, O.. - In: GUT. - ISSN 0017-5749. - STAMPA. - 55:(2006), pp. 1370-1371. [110.1136/gut.2006.099887]
Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution.
RACIOPPI, LUIGI;
2006
Abstract
Hepatitis C virus (HCV) determines an acute hepatitis evolving to persistent infection in 50–80% of patients. Different mechanisms have been proposed to explain disease evolution, including viral escape, failure of the T helper immune network, and host genetic factors. Among CD4+ T cell subsets, lymphocytes expressing constitutively CD25 (interleukin 2 receptor alpha chain), namely T regulatory cells (Treg), appear to play a critical role in controlling chronic evolution of HCV mediated liver diseases. Here we investigate the frequency and functional activity of CD3+/CD4+/CD25+ Tregs in acute HCV infection in relation to its evolution over time.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
