A simple three-step procedure for the preparation of Cprotected 2,2-2H-b3-amino acids has been developed starting from the natural a-amino acids. Our synthetic path is based on the homologation reaction of a-amino acids through the formation of dideuterated alcohol intermediates obtained by heavy isotope reduction (NaBD4) of the carboxylic function
Synthesis of C-Protected 2,2-Dideutero beta3-Amino Acids / Guaragna, Annalisa; Pedatella, Silvana; V., Pinto; Palumbo, Giovanni. - In: SYNTHESIS. - ISSN 0039-7881. - STAMPA. - 23:(2006), pp. 4013-4016. [10.1055/s-2006-950314]
Synthesis of C-Protected 2,2-Dideutero beta3-Amino Acids
GUARAGNA, ANNALISA
;PEDATELLA, SILVANA;PALUMBO, GIOVANNI
2006
Abstract
A simple three-step procedure for the preparation of Cprotected 2,2-2H-b3-amino acids has been developed starting from the natural a-amino acids. Our synthetic path is based on the homologation reaction of a-amino acids through the formation of dideuterated alcohol intermediates obtained by heavy isotope reduction (NaBD4) of the carboxylic functionFile in questo prodotto:
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