The invention discloses the use of compds. which bind to the vascular endothelial growth factor (VEGF) receptors and modulate the angiogenic response. The compds., which mimic the VEGF amino acid region 17-25 involved in receptor recognition thereby inhibiting or stimulating the angiogenic process, can be used in the treatment of diseases characterized by excessive or defective angiogenesis VEGF-dependent, such as chronic ischemia, cancer, proliferative retinopathy and rheumatoid arthritis, states or conditions benefiting from the formation or regeneration of new vessels, as well as in the diagnosis of pathologies which present a overexpression of VEGF receptors or as biochem. tools to analyze the cellular pathways dependent on VEGF receptor activation.
COMPOUNDS BASED ON VEGF HELIX 17-25 AS MODULATOR OF ANGIOGENESIS / Pedone, Carlo; D'Andrea, L. D.; Iaccarino, G.; Trimarco, Bruno; Turco, C. M.; Leone, A.. - (2007).
COMPOUNDS BASED ON VEGF HELIX 17-25 AS MODULATOR OF ANGIOGENESIS
PEDONE, CARLO;G. IACCARINO;TRIMARCO, BRUNO;
2007
Abstract
The invention discloses the use of compds. which bind to the vascular endothelial growth factor (VEGF) receptors and modulate the angiogenic response. The compds., which mimic the VEGF amino acid region 17-25 involved in receptor recognition thereby inhibiting or stimulating the angiogenic process, can be used in the treatment of diseases characterized by excessive or defective angiogenesis VEGF-dependent, such as chronic ischemia, cancer, proliferative retinopathy and rheumatoid arthritis, states or conditions benefiting from the formation or regeneration of new vessels, as well as in the diagnosis of pathologies which present a overexpression of VEGF receptors or as biochem. tools to analyze the cellular pathways dependent on VEGF receptor activation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
