A synthetic strategy to prepare o-NBS protected Fmoc-amino acids under mild conditions, in a rapid and efficient way, characterised by high yields and excellent purity of the final products has been developed. The o-NBS protected Fmoc-amino acids are employed in solid phase peptide synthesis to prepare peptidomimetics carrying mono-benzylated moieties on peptide side chains.

NEW SYNTHETIC STRATEGY FOR O-NBS PROTECTED AMINO ACIDS AND THEIR USE IN SYNTHESIS OF MONO-BENZYLATED PEPTIDES

MORELLI, GIANCARLO;
2005

Abstract

A synthetic strategy to prepare o-NBS protected Fmoc-amino acids under mild conditions, in a rapid and efficient way, characterised by high yields and excellent purity of the final products has been developed. The o-NBS protected Fmoc-amino acids are employed in solid phase peptide synthesis to prepare peptidomimetics carrying mono-benzylated moieties on peptide side chains.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/10710
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