The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5'-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2' -3' ribose bond, furnished a set of new N-1 alkylated-2' -3' -secoinosine derivatives in high yields.
Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues / Oliviero, Giorgia; Amato, Jussara; D'Errico, Stefano; Borbone, Nicola; Piccialli, Gennaro; Mayol, Luciano. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1649-1652. [10.1080/15257770701506608]
Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues
OLIVIERO, GIORGIA;AMATO, JUSSARA;D'ERRICO, STEFANO;BORBONE, NICOLA;PICCIALLI, GENNARO;MAYOL, LUCIANO
2007
Abstract
The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5'-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2' -3' ribose bond, furnished a set of new N-1 alkylated-2' -3' -secoinosine derivatives in high yields.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
