Innovative wound sealing and healing adhesives address a crucial medical need by facilitating faster and easier application while ensuring biocompatibility, biodegradability, and antibacterial efficacy. In this study, we developed a biologically inspired bonding hydrogel using carboxymethyl cellulose (CMC) as the gel matrix, integrated with green-synthesized silver nanoparticles (AgNPs), derived from an aqueous solution of Myrtus communis seed extract, and Aloe vera (AV), to enhance antimicrobial properties. The physical properties of this biodegradable hydrogel were characterized, and the antimicrobial response was evaluated against both Staphylococcus aureus and Escherichia coli . Additionally, the in vitro scratch assay using keratinocytes, fibroblasts, and endothelial cells, involved in the regeneration processes, demonstrated its wound healing potential. Our findings suggest that this green, natural-inspired engineered biodegradable hydrogel holds promise for advanced wound dressings.
A biodegradable hydrogel based on carboxymethyl cellulose/silver nanoparticles for wound closures / Maiorano, Gabriele; D'Amone, Stefania; Stradis, Claudia De; Leccese, Gabriella; Baldari, Clara; Quintarelli, Concetta; Angelis, Biagio De; Locatelli, Franco; Gigli, Giuseppe; Cortese, Barbara; Palamà, Ilaria Elena. - In: MATERIALS & DESIGN. - ISSN 0264-1275. - 262:(2026). [10.1016/j.matdes.2025.115429]
A biodegradable hydrogel based on carboxymethyl cellulose/silver nanoparticles for wound closures
Quintarelli, Concetta;Angelis, Biagio De;Locatelli, Franco;
2026
Abstract
Innovative wound sealing and healing adhesives address a crucial medical need by facilitating faster and easier application while ensuring biocompatibility, biodegradability, and antibacterial efficacy. In this study, we developed a biologically inspired bonding hydrogel using carboxymethyl cellulose (CMC) as the gel matrix, integrated with green-synthesized silver nanoparticles (AgNPs), derived from an aqueous solution of Myrtus communis seed extract, and Aloe vera (AV), to enhance antimicrobial properties. The physical properties of this biodegradable hydrogel were characterized, and the antimicrobial response was evaluated against both Staphylococcus aureus and Escherichia coli . Additionally, the in vitro scratch assay using keratinocytes, fibroblasts, and endothelial cells, involved in the regeneration processes, demonstrated its wound healing potential. Our findings suggest that this green, natural-inspired engineered biodegradable hydrogel holds promise for advanced wound dressings.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
