Several researches have been devoted to structure-activity relationship and to post-SELEX modifications of the thrombin binding aptamer (TBA), one of the first aptamers discovered by the SELEX methodol. However, no studies on TBA dealing with the effects of introduction of inversion of polarity sites have been reported yet. In this frame, we have undertaken the synthesis and the study of a mini-library composed of several TBA analogs contg. a 3'-3' or a 5'-5' inversion of polarity site at different positions into the sequence. Particularly, in this article, we present preliminary results about their structural and biol. properties.

A MINI-LIBRARY OF TBA ANALOGUES CONTAINING 3'-3' AND 5'-5' INVERSION OF POLARITY SITES

ESPOSITO, VERONICA;GALEONE, ALDO;MAYOL, LUCIANO;RANDAZZO, ANTONIO;VIRGILIO, ANTONELLA;VIRNO, ADA
2007

Abstract

Several researches have been devoted to structure-activity relationship and to post-SELEX modifications of the thrombin binding aptamer (TBA), one of the first aptamers discovered by the SELEX methodol. However, no studies on TBA dealing with the effects of introduction of inversion of polarity sites have been reported yet. In this frame, we have undertaken the synthesis and the study of a mini-library composed of several TBA analogs contg. a 3'-3' or a 5'-5' inversion of polarity site at different positions into the sequence. Particularly, in this article, we present preliminary results about their structural and biol. properties.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/104964
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