The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino- 3-alkanol derivatives, clavaminols A–F (1–6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.

Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea

AIELLO, ANNA;FATTORUSSO, ERNESTO;GIORDANO, ANTONELLA;MENNA, MARIALUISA;
2007

Abstract

The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino- 3-alkanol derivatives, clavaminols A–F (1–6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/104813
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