A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains / S., Gemma; G., Kukreja; Fattorusso, Caterina; Persico, Marco; M. P., Romano; M., Altarelli; L., Savini; G., Campiani; Fattorusso, Ernesto; N., Basilico; D., Taramelli; V., Yardleye; AND S., Butini. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 16:(2006), pp. 5384-5388. [10.1016/j.bmcl.2006.07.060]

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

FATTORUSSO, CATERINA;PERSICO, MARCO;FATTORUSSO, ERNESTO;
2006

Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs
2006
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains / S., Gemma; G., Kukreja; Fattorusso, Caterina; Persico, Marco; M. P., Romano; M., Altarelli; L., Savini; G., Campiani; Fattorusso, Ernesto; N., Basilico; D., Taramelli; V., Yardleye; AND S., Butini. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 16:(2006), pp. 5384-5388. [10.1016/j.bmcl.2006.07.060]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/104808
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