Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregulation of amino acids and energy metabolism in both pre-frail and frail participants. Remarkably, upregulated betaine levels emerged as a specific biochemical signature of pre-frail females, holding promise for the development of novel targeted interventions.
1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty / Marino, C., Imarisio, A., Gasparri, C., Napolitano, E., Di Maio, A., Avenali, M., Buongarzone, G., Galandra, C., Picascia, M., Grimaldi, M., Errico, F., Rondanelli, M., D'Ursi, A.M., Valente, E.M., Usiello, A.. - In: NPJ AGING. - ISSN 2731-6068. - 11:1(2025). [10.1038/s41514-025-00218-z]
1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty
Errico, Francesco;
2025
Abstract
Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregulation of amino acids and energy metabolism in both pre-frail and frail participants. Remarkably, upregulated betaine levels emerged as a specific biochemical signature of pre-frail females, holding promise for the development of novel targeted interventions.| File | Dimensione | Formato | |
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2025. Marino et al (npj Aging, 2025).pdf
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